Endocrine Abstracts

Some hematologic malignancies might increase the risk of fractures due to intrinsic factors of the disease but also because of the treatment with steroids or chemotherapy. The direct impact of novel targeted agents on the development of osteoporosis in these patients has not been recognized yet. A 64-years old female patient with B-cell chronic lymphocytic leukemia (B-CLL) has been followed for four years with no other comorbidities. In order to measure the burden of the disea...

A female patient presented at the age of 30 years with an incidental radiological finding of hyperostosis after a traumatic knee ligament injury. Her large facial contours with wide hands and fingers reminded acromegalic features but without typical soft tissue changes. Hormone evaluation discovered an elevated IGF-1, growth hormone (GH) was non-suppressed on glucose load, but pituitary MRI was normal. The imaging revealed remarkable cortical thickening of long bones with prom...

Retinol-binding protein 4 (RBP4) is considered as an important mediator of insulin resistance and metabolic syndrome (MS). In adipose tissue (AT)) it is mainly secreted from visceral depots. The residual metabolic risk which remains beyond that caused by visceral AT seems to be hold by upper body subcutaneous AT. This large pathogenic depot might be representative by subcutaneous neck AT.The aim of this study was to examine and to compare RBP4 gene expre...

Adipokines are an important contributor to the circulatory milieu of the body. The spectrum of adipokines changes as dysfunctional features of adipose tissue develop and the menopause is a time when an impairment of metabolic balance appears. The aim of this study was to examine several serum adipokines and adiponectin gene expression in subcutaneous and deep neck adipose tissue in women. Samples of serum, subcutaneous and deep neck adipose tissue were taken in 41 (12 premenop...

Adipose tissue distribution is one of the key determinants of metabolic dysfunction in obesity. Several large scale studies found that enlarged neck circumference is independently associated with cardiovascular risk.The aim of this study was to examine the association of neck circumference with metabolic risk factors in patients undergoing neck surgery.In 36 patients undergoing thyroid or vascular neck surgery we determined serum l...

Adipose tissue is an endocrine organ that actively contributes to the development of the metabolic dysfunction but it is not homogenous and the nature of its impact considerably depends on its anatomic location. So far both subcutaneous and deep neck adipose tissue depots were individually related to increased metabolic risk but their particular features were not mutually compared. Adiponectin is an adipocytokine that has consistently showed higher mRNA expression in subcutane...